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"Today, most people would lead to nonsedating medications." And perhaps with good reason: Some 35 states in the U. have laws related to driving while impaired -- not only by alcohol, but also from antihistamines, says Cohen. "Zyrtec is a relatively non-sedating antihistamine, but it has a warning in the Physician's Desk Reference [which gives detailed information on prescribing drugs] about operating machinery when taking it," he tells Web MD.Professional Reference articles are written by UK doctors and are based on research evidence, UK and European Guidelines.There is little evidence that antihistamines used symptomatically to treat nonspecific itching have any effect greater than placebo.Most of the second-generation antihistamines have been shown to benefit chronic idiopathic urticaria."Obviously, in the old days when you only had sedating antihistamines, that's what you used, but you generally start out by having patients take them at bedtime.And in many cases, over time the sedation became less of a problem, so they were able to take them twice a day," Cohen tells Web MD.

The review covers most of the methods described for the analysis of cetirizine (CTZ), ebastine (EBS), fexofenadine (FXD), ketotifen (KET) and loratadine (LOR) in pure forms, in different pharmaceutical dosage forms and in biological fluids.

" April 25, 2003 -- Timely research for the start of hay fever season: Despite their higher cost, the newer, so-called "second generation" of more expensive "nonsedating" prescription antihistamines may be no more effective at preventing fatigue and memory lapses than older over-the-counter formulas such as Benadryl.

So concludes a new study published in the current issue of Journal of Allergy and Clinical Immunology in which researchers compared 18 previous trials investigating antihistamine-caused sedation levels in 1,500 people between ages 8 and 81.

When given to man in oral therapeutic doses terfenadine produced about 17% H1 receptor occupancy in the frontal lobe whereas the 1st generation antihistamine chlorpheneramine produced about 77% occupancy1.

In rats, it was shown for several 1st and 2nd generation antihistamines that receptor binding continues to increase with the dose until full receptor saturation occurs2.

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