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The dominant role the theories of yin/yang and the five elements play in the physiology and pathology indicates that these medical theories are not older than about 320 BCE.

Historian of science Nathan Sivin (University of Pennsylvania) is of the opinion (1998) that the Suwen and Lingshu probably date to the first century BCE.

Its contents were then brought together by Confucian scholars in the Han Dynasty era.

Scholars of excavated medical texts Donald Harper, Vivienne Lo and Li Jianmin agree that the systematic medical theory in the Neijing shows significant variance from texts found in the Mawangdui tomb (which was sealed in 186 BCE).

Instead the natural effects of diet, lifestyle, emotions, environment, and age are the reason diseases develop.

According to the Neijing, the universe is composed of various forces and principles, such as Yin and yang, Qi and the Five Elements (or phases).

Two other texts also carried the prefix Huangdi Neijing in their titles: the Mingtang (明堂; Hall of Light) and the Taisu (太素; Grand Basis), both of which have survived only partially.

The earliest mention of the Huangdi Neijing was in the bibliographical chapter of the Hanshu 漢書 (or Book of Han, completed in 111 CE), next to a Huangdi Waijing 黃帝外經 (“Outer Canon of the Yellow Emperor”) that is now lost.

The text is structured as a dialogue between the Yellow Emperor and one of his ministers or physicians, most commonly Qíbó (Chinese: ).

Collectively, these two texts are known as the Neijing or Huangdi Neijing.

In practice, however, the title Neijing often refers only to the more influential Suwen.

These forces can be understood via rational means and man can stay in balance or return to balance and health by understanding the laws of these natural forces.

Man is a microcosm that mirrors the larger macrocosm.

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